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KMID : 0370220030470030180
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Yakhak Hoeji
2003 Volume.47 No. 3 p.180 ~ p.183
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Identification of TRAF6-Binding Motif in IL-1/Toll-like Receptor Superfamily-Mediated Signal Transduction
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Mi Jung Yim
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Abstract
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Crystal structure of TRAF6 in complex with TRAF6-binding sites from CD4O was previously determined. The structure revealed a distinct TRAF6-binding groove of CD4O, the key str uctural determinant of interaction. The structural information leads to a proposed TRAF6-binding motif. This allows the identification of TRAF6-binding sequences in the hIRAK protein, whose functional requirement in IL-1/Toll-like eceptor superfamilies-mediated signal transduction is further demonstrated using site- directed mutagenesis. The mutational effects of MRAK on the down-stream NF-KB signaling shows the importance of the TRAF6 interface for signaling by IL-1/Toll-like receptor superfamilies.
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KEYWORD
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